We are the GMMCC

The Global Mouse Models for COVID-19 Consortium

A Global Partnership of Mouse Genetics, Genomics, and Functional Assessment Centres

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Mouse Models for COVID-19

COVID-19 is an infectious disease caused by a new coronavirus, SARS-CoV-2. As of June 2020, the World Health Organization (WHO) reported infections in over 13 million people worldwide causing over 500,000 deaths. Developing and deploying preventative vaccines, reduced opportunistic infection strategies, and clinical therapeutics is benefiting from worldwide cooperation of the biomedical research and translational communities in both academia and industry.

More About COVID-19 and Mouse Models

GMMCC Aims

Mouse genetics, genomics, and functional assessment centres and repositories around the world have come together to form a consortium to underpin global research into SARS-CoV-2 by the efficient delivery of relevant mouse strains, mouse genetics expertise, and robust outcome and therapeutic effect and safety testing platforms.

These are the Global Mouse Models for COVID-19 Consortium aims to:

1

Availability & Accessibility

Provide up-to-date information and details of the availability and accessibility of mutant mouse strains relevant to SARS-CoV2

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2

New Mutant Mouse Strains

Provide information on current projects that are designing and generating new mutant mouse strains for infection, colonization, and disease-relevant host genes

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3

Support & Enhance COVID Research

Provide information on facilities and expertise that are available to support and enhance COVID-19 research and validated SARS-CoV2 infectious challenge model systems and testing platforms

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Mouse Resources for Coronavirus Research

Here is a list of resources from our member organisations and consortia who have dedicated pages to help researchers when using mice for COVID-19 research. These resources include mouse strains, publications and gene knockout data.

International Mouse Phenotyping Consortium

Mouse Phenotype Data and Strains

INFRAFRONTIER Research Infrastructure, Europe

Mouse Strains and Archiving

Mouse Genome Informatics, USA

Mouse Strains and Publications

Mutant Mouse Resource and Research Centers, USA

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  • GMMCC Members

    The GMMCC is comprised of 22 institutes and centres that represent a formidable collection of resources and expertise in mouse genetics, genomics, and response to pathogen research that are able to serve worldwide research into SARS-CoV2. See what our members can offer.

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  • GMMCC Organisations

    The GMMCC includes a number of well-established public mouse genetics consortia that provide design, production, and functional analysis of genetic mutation (IMPC, INFRAFRONTIER) and archiving and distribution of mutant mouse strains and resources of mouse for biomedical research (AMMRA, CMMR, EMMA, MMRRC).

    View GMMCC Members |

Members and Organisations

The GMMCC is comprised of 22 institutes and centres that represent a formidable collection of resources and expertise in mouse genetics, genomics, and response to pathogen research that are able to serve worldwide research into SARS-CoV2.

The GMMCC includes a number of well-established public mouse genetics consortia that provide design, production, and functional analysis of genetic mutation (IMPC, INFRAFRONTIER) and archiving and distribution of mutant mouse strains and resources of mouse for biomedical research (AMMRA based in Asia, INFRAFRONTIER-EMMA based in Europe, the MMRRC in the US, and the CMMR in Canada)

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How can mouse models help COVID-19?

The mouse is a valuable tool as an experimental model organism to improve our understanding of SARS-CoV-2 infection, colonization, pathogenesis, and host response mechanisms. The mouse can also be used to assess potential preventative, disease modifying, and therapeutic approaches.

During the SARS outbreak in 2003 caused by the SARS-CoV-1 virus, the development of a strain of mice carrying a human ACE2 gene (the receptor for Coronavirus) which was susceptible to SARS-CoV-1 proved valuable in the study of SARS. This strain will also be vital for studies of SARS-CoV-2.

Find Out More

Name Country Links
Name: Baylor College of Medicine Country: USA
Name: CAM-SU Genomic Resource Center, Soochow University Country: China
Name: Institute of Laboratory Animal Sciences-ILAS, Chinese Academy of Medical Sciences Country: China
Name: Czech Centre for Phenogenomics, IMG Country: Czech Republic
Name: CNR Monterotondo Country: Italy
Name: European Bioinformatics Institute Country: United Kingdom
Name: Helmholtz-Zentrum Muenchen Country: Germany
Name: PHENOMIN, Strasbourg Country: France
Name: Indian Institutes of Science Education and Research, Pune Country: India
Name: The Jackson Laboratory Country: USA
Name: Korea Mouse Phenotype Consortium Country: South Korea
Name: MRC Harwell Country: United Kingdom
Name: National Laboratory Animal Center, National Applied Research Laboratories (NARLabs) Country: Taiwan
Name: MARC Nanjing University Country: China
Name: PCDDP North-West University Country: South Africa
Name: Phenomics Australia Country: Australia
Name: QMUL- Queen Mary University London Country: United Kingdom
Name: RIKEN BioResource Research Center Country: Japan
Name: The Centre for Phenogenomics (TCP) Country: Canada
Name: Universitat Autònoma de Barcelona Country: Spain
Name: UC Davis Country: USA
Name: Wellcome Trust Sanger Institute Country: United Kingdom